SNAP-8 — Research, Dosing & Price Guide

SNAP-8 (Acetyl Octapeptide-3) is a cosmetic peptide that reduces the appearance of expression wrinkles by modulating neuromuscular junction signaling. It is a longer, more potent version of Argireline (Acetyl Hexapeptide-3) and works by partially inhibiting the SNARE complex responsible for vesicular neurotransmitter release. Often called 'topical Botox,' it offers a non-invasive approach to wrinkle reduction.

SNAP-8 is an octapeptide that mimics the N-terminal domain of SNAP-25, a key protein in the SNARE complex (SNAP-25, syntaxin, VAMP) that mediates synaptic vesicle fusion at the neuromuscular junction. By competing with native SNAP-25 for incorporation into the SNARE complex, SNAP-8 destabilizes the complex and reduces the efficiency of acetylcholine vesicle exocytosis. With less acetylcholine released, the muscle contraction that creates expression lines (crow's feet, forehead lines, frown lines) is attenuated. The effect is partial and dose-dependent — it does not paralyze muscles like botulinum toxin but reduces the force and frequency of micro-contractions that deepen wrinkles over time.

• In vitro studies by Lipotec (the developer) showed SNAP-8 reduced SNARE complex formation by up to 40% at 0.05 mg/mL
• Clinical study (n=24) demonstrated a 35% reduction in wrinkle depth after 28 days of twice-daily topical application at 10% concentration
• Comparative studies suggest SNAP-8 is approximately 30% more effective than Argireline (hexapeptide-3) at equivalent concentrations
• Cathelicidin expression was not affected, confirming the mechanism is specific to SNARE disruption
• The peptide demonstrates good skin penetration in cream and serum vehicles
• No systemic neuromuscular effects have been detected at topical concentrations

• Topical application: 3–10% concentration in serum or cream formulations
• Apply to clean, dry skin on target areas (forehead, crow's feet, frown lines) twice daily
• For DIY formulations: dissolve SNAP-8 powder in distilled water at 10% concentration; add 3–5% to final formulation
• Results require consistent daily application for 4–8 weeks
• Can be layered under moisturizer or sunscreen
• Some protocols combine with Argireline for enhanced SNARE complex inhibition

Known Side Effects

• Generally very well tolerated when used topically
• Mild skin irritation or redness in sensitive individuals
• Dryness or tightness if used without adequate moisturizer
• No systemic side effects reported at topical concentrations
• Effects are temporary — wrinkles return when use is discontinued

Safety Profile

SNAP-8 has an excellent safety profile for topical cosmetic use. It is classified as a cosmetic ingredient (not a drug) and has been used in commercial skincare products for over a decade. No systemic absorption or neuromuscular effects have been detected at standard topical concentrations. It does not penetrate deeply enough to affect systemic neurotransmitter release. Patch testing shows minimal allergenic potential. It is safe to use around the eyes and on sensitive facial skin. Not tested for use during pregnancy, though systemic exposure is negligible. Compatible with most other skincare actives including retinoids, vitamin C, and hyaluronic acid.

Week 1–2: No visible changes. The peptide is accumulating in the skin and beginning to modulate SNARE complex formation. Week 2–4: Subtle softening of fine expression lines, particularly around the eyes and forehead, may become noticeable. Skin may feel smoother to the touch. Week 4–8: Measurable reduction in wrinkle depth (studies show up to 35% improvement). Dynamic wrinkles (those visible during expression) improve more than static wrinkles (those visible at rest). Week 8+: Continued improvement with consistent use. Best results are maintained with ongoing daily application. Effects diminish gradually over 2–4 weeks after discontinuation.

Prices sourced from peptides.gg marketplace. Prices may vary.